Having a second screen improves medical providers’ ability to identify children with disorders who would have otherwise gone undetected. The goal of the Texas Newborn Screening Program is to identify babies who have these devastating diseases before symptoms arise so that they can receive appropriate treatment and lead productive and healthy lives. In addition, some disorders (like cystic fibrosis) rely upon both newborn screens to reduce the number of babies who would otherwise require additional testing with a specialist to determine whether they have the condition or not. In some cases, a disorder may only be detected on the second screen due to these physiological changes. These babies sometimes have a normal first screen.Īfter a baby is born, their physiology changes rapidly and sometimes it takes a week or more for these changes to occur. In Texas, the second screen routinely detects babies at risk for severe medical complications. The first screen should be collected between 24 to 48 hours of age and the second screen between 7-14 days of age. Two screens are completed in Texas to detect some of the disorders at the earliest possible opportunity. In addition, the cutoff may also be revised to reduce the number of false positive results.ĭSHS has implemented a two-screen system to maximize the effectiveness of testing for all disorders on the Texas Newborn Screening Panel. Test cutoffs are routinely re-evaluated by comparison to diagnosed case test values and false negative specimen results. If a baby has results outside this range, then those results would be considered abnormal and would require additional testing. A sufficient number of specimens representing the Texas newborn population and true positive specimens, if available, are tested to determine the range where we would expect results from babies without the disorder to fall. Cutoffs for certain disorders also require considering infant specific factors such as age of the baby at specimen collection, birthweight, prematurity and transfusion status. The study takes into account published data, the test method, and the type of equipment that will be used. In Texas, screening test cutoffs are determined by performing a study to identify the level of the analyte(s) that is indicative of the disorder. Screening test cutoffs are calculated to allow for identification of babies with the disorder while minimizing both false positive and false negative results. Health Care Information Collection (THCIC)Įach state develops their own screening test cutoffs, which are appropriate for their state’s population.National Electronic Disease Surveillance System (NEDSS).Emergency Medical Services (EMS) Licensure.Asbestos Hazard Emergency Response Act (AHERA).Food Manufacturers, Wholesalers, and Warehouses.Resources for Cancer Patients, Caregivers and Families.Cancer Resources for Health Professionals.Texas Comprehensive Cancer Control Program.
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